Mitotic-specific methylation of histone H4 Lys 20 follows increased PR-Set7 expression and its localization to mitotic chromosomes
AUTOR(ES)
Rice, Judd C.
FONTE
Cold Spring Harbor Laboratory Press
RESUMO
We describe distinct patterns of histone methylation during human cell cycle progression. Histone H4 methyltransferase activity was found to be cell cycle-regulated, consistent with increased H4 Lys 20 methylation at mitosis. This increase closely followed the cell cycle-regulated expression of the H4 Lys 20 methyltransferase, PR-Set7. Localization of PR-Set7 to mitotic chromosomes and subsequent increase in H4 Lys 20 methylation were inversely correlated to transient H4 Lys 16 acetylation in early S-phase. These data suggest that H4 Lys 20 methylation by PR-Set7 during mitosis acts to antagonize H4 Lys 16 acetylation and to establish a mechanism by which this mark is epigenetically transmitted.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=186671Documentos Relacionados
- PR-Set7-dependent methylation of histone H4 Lys 20 functions in repression of gene expression and is essential for mitosis
- A novel histone H4 mutant defective in nuclear division and mitotic chromosome transmission.
- Methylation of histone H3 Lys 4 in coding regions of active genes
- Set2-Catalyzed Methylation of Histone H3 Represses Basal Expression of GAL4 in Saccharomyces cerevisiae
- H3 and H4 histone cDNA sequences from Xenopus: a sequence comparison of H4 genes.