Modulation of neuromuscular transmission by endogenous and exogenous prostaglandins in the guinea-pig mesenteric artery

AUTOR(ES)
RESUMO

1. At concentrations of 2·8 × 10-8-2·8 × 10-6 M, prostaglandins (PGs; PGE1, PGE2 and PGF2α) had no effect on membrane potential and resistance of smooth muscles of the guinea-pig mesenteric artery. PGs (2·8 × 10-8 M) suppressed the contraction evoked by perivascular nerve stimulation, but did not suppress the contraction evoked by direct muscle stimulation.

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