Modulation of the immune response by a synthetic adjuvant and analogs.
AUTOR(ES)
Chedid, L
RESUMO
N-Acetylmuramyl-L-alanyl-D-isoglutamine increases the humoral immune response of mice when given in aqueous media instead of the usual water-in-oil emulsions. Moreover, this compound is adjuvant active even by the oral route. In view of studying the relation between chemical structure and biological activity, several synthetic analogs were tested. The immune response could be modulated according to chemical modifications, and the synthetic analog with D- in place of L-alanine was shown to inhibit the immune response.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=430612Documentos Relacionados
- Stimulation of chemiluminescence by synthetic muramyl dipeptide and analogs.
- On the rapid deprotection of synthetic oligonucleotides and analogs.
- Morphinomimetic activity of synthetic fragments of beta-lipotropin and analogs.
- Inhibition of T-cell reactivity to myasthenogenic epitopes of the human acetylcholine receptor by synthetic analogs.
- Immunopharmacological activities of a synthetic counterpart of a biosynthetic lipid A precursor molecule and of its analogs.