Molecular Analysis of 36 Mutations at the Mouse Pink-Eyed Dilution (P) Locus
AUTOR(ES)
Johnson, D. K.
RESUMO
Thirty-six radiation- or chemically induced homozygous-lethal mutations at the p locus in mouse chromosome 7 have been analyzed at 17 loci defined by molecular probes to determine the types of lesions, numbers of p-region markers deleted or rearranged, regions of overlap of deletion mutations, and genetic distances between loci. A linear deletion map of the [Myod1, Ldh3]-[Snrpn, Znf127] region has been constructed from the molecular analyses of the p-locus deletions. The utility of these deletions as tools for the isolation and characterization of the genes specifying the neurological, reproductive, and developmental phenotypes genetically mapped to this region will grow as more detailed molecular analyses continue.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1206887Documentos Relacionados
- Genetic and molecular analysis of recessive alleles at the pink-eyed dilution (p) locus of the mouse.
- Complementation Analyses for 45 Mutations Encompassing the Pink-Eyed Dilution (P) Locus of the Mouse
- Effects on Sperm Morphology by Alleles at the Pink-Eyed Dilution Locus in Mice
- Pink-eyed Dilution Protein Controls the Processing of Tyrosinase
- Carcinogens induce reversion of the mouse pink-eyed unstable mutation