Molecular and Genomic Analysis of Genes Encoding Surface-Anchored Proteins from Clostridium difficile
AUTOR(ES)
Karjalainen, Tuomo
FONTE
American Society for Microbiology
RESUMO
The gene slpA, encoding the S-layer precursor protein in the virulent Clostridium difficile strains C253 and 79–685, was identified. The precursor protein carries a C-terminal highly conserved anchoring domain, similar to the one found in the Cwp66 adhesin (previously characterized in strain 79–685), an SLH domain, and a variable N-terminal domain mediating cell adherence. The genes encoding the S-layer precursor proteins and the Cwp66 adhesin are present in a genetic locus carrying 17 open reading frames, 11 of which encode a similar two-domain architecture, likely to include surface-anchored proteins.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=98308Documentos Relacionados
- Transcription and Analysis of Polymorphism in a Cluster of Genes Encoding Surface-Associated Proteins of Clostridium difficile
- Molecular Analysis of Clostridium difficile Strains Isolated from 18 Cases of Recurrent Clostridium difficile-Associated Diarrhea
- Molecular cloning and genetic analysis of a chloramphenicol acetyltransferase determinant from Clostridium difficile.
- Binding of Clostridium difficile Surface Layer Proteins to Gastrointestinal Tissues
- Isolation of recombinant antibodies directed against surface proteins of Clostridium difficile