Molecular scanning of candidate mitochondrial tRNA genes in type 2 (non-insulin dependent) diabetes mellitus.

AUTOR(ES)

Thomas, A W

RESUMO

Mitochondrial DNA (mtDNA) gene defects may play a role in the development of non-insulin dependent diabetes mellitus (NIDDM). In order to search for potentially diabetogenic mtDNA defects we have applied the technique of single stranded conformational polymorphism (SSCP) analysis to 124 patients with a history of NIDDM and 40 non-diabetic controls. No new heteroplasmic mutations were detected. However, a variety of homoplasmic variants were found in patients with NIDDM; some of these merit further investigation.

Documentos Relacionados

• The genetics of type I (insulin dependent) diabetes mellitus.
• Secretor state of patients with insulin dependent or non-insulin dependent diabetes mellitus.
• Characterization of cellular defects of insulin action in type 2 (non-insulin-dependent) diabetes mellitus.
• The contribution of genetic factors to the pathogenesis of type I (insulin dependent) diabetes mellitus.
• Studies of the human liver insulin receptor in noninsulin-dependent diabetes mellitus.