Molecular studies into the role of CD44 variants in metastasis in gastric cancer.
AUTOR(ES)
Hsieh, H F
RESUMO
CD44, an integral membrane glycoprotein expressed by many cell types, serves as the principal transmembrane hyaluronate receptor and might be a determinant of metastatic and invasive behaviour in carcinomas. The generation of CD44 splice variants might be linked closely with gastric carcinoma tumorigenesis and differentiation. Some studies have reported that the magnitude of CD44 variant synthesis at the protein level correlates with lymph node metastasis. A number of studies have examined the possible mechanism of involvement of the CD44 variant in tumour metastasis. Most studies have reported that the regulation of CD44 binding to hyaluronate results from glycosylation of variably spliced exons. Direct hyaluronate binding studies of CD44 V4-V7 isoforms transfected into the human gastric carcinoma cell line, SC-M1, have indicated that the V4-V7 isoforms themselves, in addition to glycosylation, can alter hyaluronate binding.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=395666Documentos Relacionados
- Differential expression of CD44 variants among meningioma subtypes
- De novo expression of CD44 in prostate carcinoma is correlated with systemic dissemination of prostate cancer.
- Trans-acting factors regulate the expression of CD44 splice variants.
- The normal structure and function of CD44 and its role in neoplasia.
- Análise da expressão da molécula CD44 e suas isoformas no câncer de próstata