Moloney leukemia virus immortalizes B lymphocytes in vitro.
AUTOR(ES)
Runnels, J
RESUMO
An in vitro culture system in which Moloney murine leukemia virus induces immortalization of mature B lymphocytes has been developed. The cell lines derived in this way are nontumorigenic, and virus production is not required to sustain them. This system provides a new in vitro model with which to study the stepwise process of transformation by retroviruses lacking oncogenes.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=249058Documentos Relacionados
- Sequence requirements for integration of Moloney murine leukemia virus DNA in vitro.
- RNA-primed initiation of Moloney murine leukemia virus plus strands by reverse transcriptase in vitro.
- Rearrangements and insertions in the Moloney murine leukemia virus long terminal repeat alter biological properties in vivo and in vitro.
- Moloney murine leukemia virus activates NF-kappa B.
- Synthesis of Rauscher murine leukemia virus-specific polypeptides in vitro.
