Monofenilbutazona em pôneis: avaliação de efeitos colaterais / Monophenylbutazone in ponies: evaluation of side effects

AUTOR(ES)
DATA DE PUBLICAÇÃO

2007

RESUMO

This work aimed to evaluate the occurrence of side effects caused by monophenylbutazone on the digestive and kidney tract of ponies, and to verify the relation between omeprazole with inhibition of the formation of gastric ulcers. The experiment was carried out in two phases. In the first, six normal ponies were used, with three being treated daily via intravenous (IV) monophenylbutazone doses of 3, 4.5 or 6 mg kg-1 during 12 days. The other ponies were also given 3 mg kg-1 of omeprazole, besides the antiinflamatory drug. In the second phase, four ponies were included, with two being treated with daily doses of 4.5 mg kg-1 of monophenylbutazone during 12 days, and the remainder with 5 mL of NaCl at 0.9 %, via the IV route. All ponies were submitted to endoscopy before and after each experimental phase. Additionally, in the first phase, urine analysis and determination of blood (globular volume, total leucocytes, total plasma proteins) and serum (urea and creatinine, aspartate aminotransferase, Ca+2, P+3, Cl-, Na+ and K+) variable values were performed before, during and after the experiment. In the first phase, only the two ponies treated with 6 mg kg-1 of monophenylbutazone presented ulcers in the aglandular region, along the margo plicatus, being more serious in the animal not given omeprazole. In the second phase, two animals also presented gastric ulcers, with one having received only the physiological solution. Statistical analysis showed that the appearance of ulcers was not influenced (P>0.05) by administration and dose of monophenylbutazone, nor by the presence of omeprazole. The effect of the former on the blood and serum variables was small or inexpressive. The results obtained allowed to conclude that the occurrence of gastric ulcer in the aglandular region of ponies was not influenced by application and dose of monophenylbutazone when administered during 12 days; ulcers in the aglandular region of ponies do not present clinical symptomatology; ponies tolerate the application of 6 mg kg-1 of monophenylbutazone during 12 days without the appearance of kidney lesion; the effect of monophenylbutazone on the blood and serum variables is small or absent, since, in general, such variables are kept within values considered as reference for the species; the relation of omeprazole with the presence or absence of ulcer was not confirmed.

ASSUNTO(S)

omeprazol omeprazole equine clinica veterinaria kidney lesion Úlceras gástricas nonsteroidal anti- inflammatory drugs problema renal gastric ulcers equino anti-inflamatórios não esteroidais

ACESSO AO ARTIGO

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