Morphological Changes Induced by Dextran Sulfate 500 in Mononuclear Phagocytes of Listeria-Infected Mice
AUTOR(ES)
Hahn, Helmut
RESUMO
Morphological changes involving mononuclear phagocytes in Listeria-infected mice after treatment with dextran sulfate 500 were investigated. Mononuclear phagocytes in livers and spleens, both circulating monocytes and fixed macrophages, showed uptake of electron-dense material. Mononuclear phagocyte changes were most pronounced within granulomatous lesions, where many phagocytes showed large membrane-bound inclusions and extensive cellular damage. It is concluded that dextran sulfate 500 selectively damages mononuclear phagocytes and that, in listerial infection, dextran sulfate 500 renders mononuclear phagocytes unable to express cellular resistance.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=423070Documentos Relacionados
- Effects of Antithymocyte Sera and Antimacrophage Sera on Cell-Mediated Immune Reactions in Listeria-Infected Mice
- Effects of Dextran Sulfate 500 on Cell-Mediated Resistance to Infection with Listeria monocytogenes in Mice
- In Vitro Proliferation of T Lymphocytes from Listeria-Infected Rodents: Assay Conditions for Rat Peritoneal Exudate Cells and Characterization of an Inhibitor
- Suppression of liver uptake of liposomes by dextran sulfate 500.
- Dissemination of Listeria monocytogenes by Infected Phagocytes
