Morphology, Motility, and Surface Behavior of Lymphocytes Bound to Nylon Fibers
AUTOR(ES)
Rutishauser, U.
RESUMO
Mouse B lymphocytes that were specifically bound to dinitrophenylated bovine serum albumin on nylon fibers exhibited continuous morphological changes, whereas bound T lymphocytes remained more or less spherical. Cinematomicrographic studies showed that the shape changes were associated with local and global movements, although the attached cells did not translocate along the fiber. Cap formation induced by anti-immunoglobulin was always found to be opposite to the point of attachment. The movements and the shape changes were prevented by cytochalasin B and colchicine. Treatment with these agents did not prevent cap formation but led to randomization of the position of the caps with respect to the fiber. Exposure to concanavalin A or attachment of cells to concanavalin A fibers prevented both movement and patch and cap formation, suggesting that cellular structures regulating the mobility of various receptors are altered by binding to concanavalin A fibers. These observations also indicate that interactions of local areas of the lymphocyte surface with certain ligands and substrates can strongly affect the movement and morphology of the entire cell.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=388181Documentos Relacionados
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