Morphometric variability of minicolumns in the striate cortex of Homo sapiens, Macaca mulatta, and Pan troglodytes
AUTOR(ES)
Casanova, Manuel F
FONTE
Blackwell Science Inc
RESUMO
Radially oriented ensembles of neurons and their projections, termed minicolumns, are hypothesized to be the basic microcircuit of mammalian cerebral cortex. Minicolumns can be divided into a core and a peripheral neuropil space compartment. The core of minicolumns is constrained by the migratory path of pyramidal cells and their attendant radially oriented projections. Variation in minicolumnar morphometry and density is observed both within and across species. Using a scale-independent measure of variability in minicolumnar width (VCW), we demonstrated a significant increase in VCW in layers III–V of striate cortex in humans relative to macaques and chimpanzees. Despite changes in minicolumnar width (CW) across species, their core space (w) remained the same. Given that cellular elements and processes within the peripheral neuropil space of minicolumns are derived from assorted sources, cross-species differences in VCW may result from genetic and epigenetic influences acting primarily on this compartment of the minicolumn.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2667880Documentos Relacionados
- Homo sapiens, Homo demens e Homo degradandis: a psiquê humana e a crise ambiental
- Biologic data of Macaca mulatta, Macaca fascicularis, and Saimiri sciureusused for research at the fiocruz primate center
- The Course of Fibres in the Dorsal Nerve Roots of Macaca Mulatta, the Rhesus Monkey
- Homo sapiens, Homo neanderthalensis and the Denisova specimen: new insights on their evolutionary histories using whole-genome comparisons
- The adrenal glands of Macaca mulatta, with special reference to the cortico-medullary zone.