Murine Model of Bartonella henselae Infection in the Immunocompetent Host
AUTOR(ES)
Regnath, T.
FONTE
American Society for Microbiology
RESUMO
Bartonella henselae is an emerging pathogen causing cat scratch disease, bacillary angiomatosis, and peliosis hepatis. Progress in understanding the pathogenesis of and the immune response to these infections has been limited by the lack of an animal model. Following intraperitoneal infection of C57BL/6 mice with B. henselae, organs were cleared of cultivatable bacteria within 6 days. In contrast, B. henselae DNA could be detected in liver tissue for at least 3 months. Liver tissue showed granulomatous inflammation reaching its highest degree of intensity during the fourth week of infection and resolving within 12 weeks postinfection. This mouse model is applicable to the study of the pathogenesis of B. henselae and the immune response to this pathogen in the immunocompetent host.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=108694Documentos Relacionados
- In Vitro Model of Bartonella henselae-Induced Angiogenesis
- Osteomyelitis Caused by Bartonella henselae Genotype I in an Immunocompetent Adult Woman
- Interaction of Bartonella henselae with the Murine Macrophage Cell Line J774: Infection and Proinflammatory Response
- Infecção experimental dos eritrocitos humanos pela Bartonella henselae
- Clinical and Pathologic Evaluation of Chronic Bartonella henselae or Bartonella clarridgeiae Infection in Cats
