Mutation of sarA in Staphylococcus aureus Limits Biofilm Formation
AUTOR(ES)
Beenken, Karen E.
FONTE
American Society for Microbiology
RESUMO
Mutation of sarA resulted in a reduced capacity to form a biofilm in six of the eight Staphylococcus aureus strains we tested (UAMS-1, UAMS-601, SA113, SC-01, S6C, and DB). The exceptions were Newman, which formed a poor biofilm under all conditions, and RN6390, which consistently formed a biofilm only after mutation of agr. Mutation of agr in other strains had little impact on biofilm formation. In every strain other than Newman, including RN6390, simultaneous mutation of sarA and agr resulted in a phenotype like that observed with the sarA mutants. Complementation studies using a sarA clone confirmed that the defect in biofilm formation was due to the sarA mutation.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=161964Documentos Relacionados
- Characterization of Staphylococcus aureus SarA Binding Sites
- Role of sarA in the Pathogenesis of Staphylococcus aureus Musculoskeletal Infection
- sarU, a sarA Homolog, Is Repressed by SarT and Regulates Virulence Genes in Staphylococcus aureus
- Regulation of Staphylococcus aureus Capsular Polysaccharide Expression by agr and sarA
- SarS, a SarA Homolog Repressible by agr, Is an Activator of Protein A Synthesis in Staphylococcus aureus