Mutator Activity of Petite Strains of SACCHAROMYCES CEREVISIAE
AUTOR(ES)
Flury, Fred
RESUMO
Petite strains in Saccharomyces exhibit enhanced spontaneous mutation rates of nuclear genes regardless of whether they are cytoplasmically or nuclearly inherited, or whether or not the cytoplasmic petite strains have mitochondrial DNA. In petite strains, the mutation rate for the nonsense allele lys1-1 is enhanced by a factor of 3-6 and for the missense allele his1-7 by a factor of 2 as compared with their grande counterparts. The reversion of a third allele, the putative frameshift mutation, hom3-10 , is not enhanced in a petite background. The results indicate that the spontaneous mutation rate of an organism can be altered by indirect intracellular influences.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1213540Documentos Relacionados
- Elevated Levels of Petite Formation in Strains of SACCHAROMYCES CEREVISIAE Restored to Respiratory Competence. II. Organization of Mitochondrial Genomes in Strains Having High and Moderate Frequencies of Petite Mutant Formation
- Cytoplasmic “Petite” Induction in Recombination-Deficient Mutants of Saccharomyces cerevisiae
- Genetic Analysis of Petite Mutants of SACCHAROMYCES CEREVISIAE : Transmissional Types
- Induction of petite mutations during germination and outgrowth of Saccharomyces cerevisiae ascospores.
- Tandem Inverted Repeats in Mitochondrial DNA of Petite Mutants of Saccharomyces cerevisiae*
