Mycobacterial phosphatidylinositol mannoside is a natural antigen for CD1d-restricted T cells
AUTOR(ES)
Fischer, Karsten
FONTE
National Academy of Sciences
RESUMO
A group of T cells recognizes glycolipids presented by molecules of the CD1 family. The CD1d-restricted natural killer T cells (NKT cells) are primarily considered to be self-reactive. By employing CD1d-binding and T cell assays, the following structural parameters for presentation by CD1d were defined for a number of mycobacterial and mammalian lipids: two acyl chains facilitated binding, and a polar head group was essential for T cell recognition. Of the mycobacterial lipids tested, only a phosphatidylinositol mannoside (PIM) fulfilled the requirements for CD1d binding and NKT cell stimulation. This PIM activated human and murine NKT cells via CD1d, thereby triggering antigen-specific IFN-γ production and cell-mediated cytotoxicity, and PIM-loaded CD1d tetramers identified a subpopulation of murine and human NKT cells. This phospholipid, therefore, represents a mycobacterial antigen recognized by T cells in the context of CD1d.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=489995Documentos Relacionados
- Identification and Simian Immunodeficiency Virus Infection of CD1d-Restricted Macaque Natural Killer T Cells
- CD1d-restricted T cell activation by nonlipidic small molecules
- Role of CD1d-Restricted NKT Cells in Microbial Immunity
- Bacterial glycolipids and analogs as antigens for CD1d-restricted NKT cells
- Adaptability of the semi-invariant natural killer T-cell receptor towards structurally diverse CD1d-restricted ligands
