Myelin basic protein immunoreactivity in serum of neurosurgical patients.

AUTOR(ES)

Thomas, D G

RESUMO

Patients admitted to the neurosurgical wards for the management of nervous system tumours, subarachnoid and intracerebral haemorrhage, head injury, spinal and peripheral nerve lesions, and other miscellaneous neurosurgical conditions, were studied by assay of serum immunoreactivity for myelin basic protein. Of 171 patients, 70% proved to have elevated myelin basic protein activity. In cerebral cases the extent of brain damage assessed by clinical methods appeared to correlate with the appearance of elevated serum myelin basic protein. In spinal and peripheral nerve cases no similar elevation of myelin basic protein was observed.

Documentos Relacionados

• Monitoring of intracranial pressure in neurosurgical patients.
• Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-beta1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients.
• Characterization of mouse myelin basic protein messenger RNAs with a myelin basic protein cDNA clone.
• Decreased dependence of myelin basic protein-reactive T cells on CD28-mediated costimulation in multiple sclerosis patients. A marker of activated/memory T cells.
• Myelin protein zero gene mutated in Charcot-Marie-tooth type 1B patients.