Nef Enhances Human Immunodeficiency Virus Type 1 Infectivity in the Absence of Matrix
AUTOR(ES)
Dorfman, Tatyana
FONTE
American Society for Microbiology
RESUMO
Nef enhances the serine phosphorylation of the human immunodeficiency virus type 1 matrix (MA) protein, which suggests that MA may be a functional target of Nef. Using mutants that remain infectious despite the absence of most or all of MA, we show in the present study that the ability of Nef to enhance virus infectivity is not compromised even if MA is entirely replaced by a heterologous lipid anchor.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=136271Documentos Relacionados
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