Neurotrophins regulate Schwann cell migration by activating divergent signaling pathways dependent on Rho GTPases

AUTOR(ES)

Yamauchi, Junji

FONTE

National Academy of Sciences

RESUMO

Neurotrophins are recognized widely as essential factors in the developing nervous system. Previously, we demonstrated that neurotrophin 3 activation of TrkC inhibits Schwann cell myelination and enhances the migration of primary Schwann cells through the signaling pathway regulated by the Rho GTPases Rac1 and Cdc42. Here, we show that neurotrophins activate divergent signaling pathways to promote or inhibit Schwann cell migration. Endogenous brain-derived neurotrophic factor acting through p75NTR inhibits Schwann cell migration dramatically by Src kinase-dependent activation of the guanine-nucleotide exchange factor Vav2 and RhoA. Together, these results suggest that neurotrophins and their receptors differentially regulate Schwann cell migration through the signaling pathways that depend on Rho GTPases.

Documentos Relacionados

• Divergent cAMP signaling pathways regulate growth and pathogenesis in the rice blast fungus Magnaporthe grisea.
• Signaling Specificity by Ras Family GTPases Is Determined by the Full Spectrum of Effectors They Regulate
• Rho Family GTPases Are Required for Activation of Jak/STAT Signaling by G Protein-Coupled Receptors
• p250GAP, a Novel Brain-enriched GTPase-activating Protein for Rho Family GTPases, Is Involved in the N-Methyl-d-aspartate Receptor Signaling
• Schwann cell survival mediated by the signaling phospholipid lysophosphatidic acid