New clues to the puzzle of mammalian sex determination
AUTOR(ES)
Bowles, Josephine
FONTE
BioMed Central
RESUMO
WT1 and SOX9 are transcription factors with critical roles in mammalian sex determination and gonadal development. Recent studies in vivo clarify the roles of two alternative splice isoforms of WT1, and demonstrate that SOX9 can induce male sex determination.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=138963Documentos Relacionados
- Fungus Holds Clues to the Evolution of Sex Chromosomes
- Elucidation of the transcription network governing mammalian sex determination by exploiting strain-specific susceptibility to sex reversal
- New clues to the function of the Cajal body
- A new piece in the hypertension puzzle: central blood pressure regulation by sex steroids
- The human sex-reversing ATRX gene has a homologue on the marsupial Y chromosome, ATRY: Implications for the evolution of mammalian sex determination