Normal oxidative damage to mitochondrial and nuclear DNA is extensive.
AUTOR(ES)
Richter, C
RESUMO
Oxidative damage to DNA can be caused by excited oxygen species, which are produced by radiation or are by-products of aerobic metabolism. The oxidized base, 8-hydroxydeoxyguanosine (oh8dG), 1 of approximately 20 known radiation damage products, has been assayed in the DNA of rat liver. oh8dG is present at a level of 1 per 130,000 bases in nuclear DNA and 1 per 8000 bases in mtDNA. Mitochondria treated with various prooxidants have an increased level of oh8dG. The high level of oh8dG in mtDNA may be caused by the immense oxygen metabolism, relatively inefficient DNA repair, and the absence of histones in mitochondria. It may be responsible for the observed high mutation rate of mtDNA.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=281993Documentos Relacionados
- Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress
- Mitochondrial Dysfunction Due to Oxidative Mitochondrial DNA Damage Is Reduced through Cooperative Actions of Diverse Proteins
- The mitochondrial DNA polymerase as a target of oxidative damage
- Mitochondrial targeting of human DNA glycosylases for repair of oxidative DNA damage.
- Oxidative damage and mitochondrial decay in aging.