Novel biological property of pertussis toxin: chemotactic activity on human monocytes.

AUTOR(ES)

Ogawa, T

RESUMO

Pertussis toxin isolated from Bordetella pertussis phase I strain Tohama enhanced the migration of human blood monocytes in an assay with a multiwell chemotaxis assembly. The monocyte migration enhancement by pertussis toxin was abolished by heating at 100 degrees C for 30 min, which caused a complete loss of the other biological activities of pertussis toxin. Checkerboard analysis demonstrated that the increased monocyte migration caused by pertussis toxin was directed toward a positive stimulus: chemotaxis.

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