Novel targeted agents for the treatment of bladder cancer: translating laboratory advances into clinical application

AUTOR(ES)

Yang, Xiaoping, Flaig, Thomas W.

FONTE

International braz j urol

DATA DE PUBLICAÇÃO

2010-06

RESUMO

Bladder cancer is a common and frequently lethal cancer. Natural history studies indicate two distinct clinical and molecular entities corresponding to invasive and non-muscle invasive disease. The high frequency of recurrence of noninvasive bladder cancer and poor survival rate of invasive bladder cancer emphasizes the need for novel therapeutic approaches. These mechanisms of tumor development and promotion in bladder cancer are strongly associated with several growth factor pathways including the fibroblast, epidermal, and the vascular endothelial growth factor pathways. In this review, efforts to translate the growing body of basic science research of novel treatments into clinical applications will be explored.

Documentos Relacionados

• Molecular tumor profiling: translating genomic insights into clinical advances
• General Surgery—Important Advances in Clinical Medicine: Adrenalectomy for Metastatic Breast Cancer: Surgical Versus Medical Treatment
• Understanding Breast Cancer: Clinical and Laboratory Concepts
• Systemic treatment for invasive bladder cancer: neoadjuvant chemotherapy and laparoscopic radical cystectomy
• Clinical practice guidelines for the care and treatment of breast cancer: 11. Lymphedema