Nuclear receptor ligand-binding domains: reduction of helix H12 dynamics to favour crystallization

AUTOR(ES)

Nahoum, Virginie

FONTE

International Union of Crystallography

RESUMO

Attempts have been made to crystallize the ligand-binding domain of the human retinoid X receptor in complex with a variety of newly synthesized ligands. An inverse correlation was observed between the ‘crystallizability’ and the structural dynamics of the various receptor–ligand complexes.

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