Nucleotide sequence and distinctive characteristics of the env gene of endogenous feline leukemia provirus.
AUTOR(ES)
Kumar, D V
RESUMO
Nucleotide sequence analysis of the env gene of two different endogenous feline leukemia virus (FeLV) loci, CFE-6 and CFE-16, of domestic cats revealed the following characteristics. (i) Both proviruses contain an open reading frame in the env region; (ii) whereas the full complement of the exogenous FeLV env is generally present in CFE-6 DNA, it is truncated in CFE-16 DNA such that the 5' half of the gp70 domain and the untranslated region 3' to the p15E domain have been fused by an internal deletion, resulting in loss of the C-terminal half of the gp70- and all of the p15E-coding sequences; (iii) endogenous env is highly homologous to large sequence domains conserved in all three exogenous FeLV subgroups (A, B, and C) but is similar to FeLV-B sequence domains in the variable regions detected in these viruses; and (iv) there are four other sequence domains, one residing at the C terminus of gp70 and three scattered in p15E, which are unique for the endogenous env, thereby distinguishing it from the FeLV-B gene.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=250662Documentos Relacionados
- Nucleotide Sequence and Distinctive Characteristics of the env Gene of Endogenous Feline Leukemia Provirus
- Nucleotide sequence of a transduced myc gene from a defective feline leukemia provirus.
- Host restriction of Friend leukemia virus: synthesis and integration of the provirus.
- Nucleotide sequence of the gag gene and gag-pol junction of feline leukemia virus.
- Murine leukemia virus: detection of unintegrated double-stranded DNA forms of the provirus.
