Nucleotide sequence of the SHV-5 beta-lactamase gene of a Klebsiella pneumoniae plasmid.
AUTOR(ES)
Billot-Klein, D
RESUMO
The nucleotide sequence of the SHV-5 beta-lactamase gene, subcloned from a plasmid of Klebsiella pneumoniae, was determined. The amino acid changes thought to be responsible for the extended substrate profile of SHV-5 are Gly----Ser234 and Glu----Lys235. SHV-5 is identical to SHV-4, except for Leu----Arg201, which accounts for the difference in apparent pI of the two enzymes.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=172080Documentos Relacionados
- Nucleotide sequence of SHV-2 beta-lactamase gene.
- Nucleotide sequence of the gene encoding the SHV-2 beta-lactamase (blaSHV-2) of Klebsiella ozaenae.
- Emergence of an inhibitor-resistant beta-lactamase (SHV-10) derived from an SHV-5 variant.
- Molecular epidemiology of Klebsiella pneumoniae producing SHV-5 beta- lactamase: parallel outbreaks due to multiple plasmid transfer.
- Hospital outbreak of Klebsiella pneumoniae resistant to broad-spectrum cephalosporins and beta-lactam-beta-lactamase inhibitor combinations by hyperproduction of SHV-5 beta-lactamase.
