Overreplication and recombination of DNA in higher eukaryotes: potential consequences and biological implications.

AUTOR(ES)

Schimke, R T

RESUMO

We propose that a fundamental problem in the faithful replication of complex chromosomes of higher eukaryotes is the proper control of both the number and timing of the multiple initiations of replication on single chromosomes. When replication patterns are disrupted by any of a variety of agents, overreplication of DNA can occur. We propose a model that accounts for the generation of a wide variety of chromosomal aberrations-rearrangements, resulting from the various ways in which the overreplicated strands can undergo recombination. We also discuss certain implications of the generation of chromosomal alterations in higher eukaryotes as they may relate to cancer chemotherapy, cancer progression, aging, and rapid speciation-evolution.

Documentos Relacionados

• Tetracycline-controlled transcription in eukaryotes: novel transactivators with graded transactivation potential.
• DNA mesophases induced by spermidine: structural properties and biological implications.
• RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression.
• DNA replication in eukaryotes: a model for the specific involvement of chromatin subunits.
• DNA Methylation in Eukaryotes: Kinetics of Demethylation and De Novo Methylation during the Life Cycle