p53 expression in dyskeratosis congenita: a marker for oral premalignancy?
AUTOR(ES)
Ogden, G R
RESUMO
As p53 expression has been associated with malignant disease its presence was assessed in biopsy specimens from dorsal lingual hyperkeratosis, taken over a five year period. p53 expression, using CM1, was assessed using a standard immunoperoxidase technique. p53 was not identified in the first biopsy specimen in 1986 but was identified in all subsequent ones. Only in the latest biopsy specimen was there evidence for dysplasia in haematoxylin and eosin stained sections. It is suggested that p53 expression may be a reliable marker for predicting premalignant change in keratoses occurring in dyskeratosis congenita.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=501151Documentos Relacionados
- Dyskeratosis congenita: three additional families show linkage to a locus in Xq28.
- p53 expression in lymphatic malignancies.
- Identification of a novel p53 promoter element involved in genotoxic stress-inducible p53 gene expression.
- Dyskeratosis congenita: clinical features and genetic aspects. Report of a family and review of the literature.
- Dyskeratosis congenita.