Parvovirus associated antigen in the synovial membrane of patients with rheumatoid arthritis.
AUTOR(ES)
Stierle, G
RESUMO
Homogenates of synovium from patients with rheumatoid arthritis (RA) and osteoarthritis (OA) were centrifuged on caesium chloride density gradients to obtain isolates of a density similar to that of parvoviruses. Six of 11 RA isolates and none of six OA isolates reacted with an antiserum raised against a rheumatoid associated, parvovirus-like agent (RA-1 virus). An anti-B19 parvovirus antiserum did not react with any of the isolates tested. Electron microscopy of negatively stained preparations of the isolates showed that small particles of diameter 10 nm were abundant in most of the RA isolates (11/13) but absent from all OA isolates. Such particles, whose identification is unknown, were also present in RA-1 positive lysates prepared from cultured RA synovial cells. These results suggest that the RA-1 virus can be directly identified in RA synovial tissue and that the virus appears to be unrelated to the human B19 parvovirus.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1002103Documentos Relacionados
- Detection of cytokine producing cells in the synovial membrane from patients with rheumatoid arthritis.
- Ultrastructure of synovial membrane in rheumatoid arthritis.
- Differentiation of B cells in the nonlymphoid tissue of the synovial membrane of patients with rheumatoid arthritis.
- A tissue kallikrein in the synovial fluid of patients with rheumatoid arthritis.
- Complement system in synovial fluids from patients with rheumatoid arthritis.