Passage through mitosis is required for oncoretroviruses but not for the human immunodeficiency virus.
AUTOR(ES)
Lewis, P F
RESUMO
The human immunodeficiency virus productively infects and integrates into cells that have been arrested in the cell cycle with either gamma irradiation or aphidicolin. Integration by oncoretroviruses such as the murine leukemia virus (MuLV), on the other hand, depends on cell proliferation. Although the entire cell cycle is not necessary for MuLV infection, it is essential that the infected cells pass through mitosis. The long terminal repeat circle junction, a marker for nuclear entry, is first observed in MuLV-infected cells immediately after mitosis. These results suggest that mitosis is necessary for nuclear entry of MuLV, but not human immunodeficiency virus, unintegrated proviral DNA.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=236313Documentos Relacionados
- Human Enhancer of Invasion-Cluster, a Coiled-Coil Protein Required for Passage through Mitosis
- The Sda1 Protein Is Required for Passage through Start
- Cohesin release is required for sister chromatid resolution, but not for condensin-mediated compaction, at the onset of mitosis
- Nuclear Export of Human Immunodeficiency Virus Type 1 Vpr Is Not Required for Virion Packaging
- The neonatal Fc receptor is not required for mucosal infection by mouse mammary tumor virus.