Perfis sericos lipidico, apoproteico e lipoproteico de pacientes portadores do virus da imunodeficiencia adquirida

AUTOR(ES)
DATA DE PUBLICAÇÃO

2000

RESUMO

Treatment with highly active anti-retrovkal therapy drugs (HAART) has resulted in decrease of the viralload of human immunodeficiency virus (IDV) until its negativatio~ with concomitant rebuilding of the immune system. Potency and effectiveness of anti-retroviral therapies of high activity increase the life expectation of mv infected patients. However, results of several studies and case reports suggest that these therapies can a1so produce metabolic disorders such as hyperlipidemia, hyperglycemia and insulin resistance, as well as body composition abnormalities like enlargement of the abdominal circumference, buffalo hump, total or out1ying lipodystrophy, lipomatoses and fat deposition in the breasts.ofwomen. Some modifications of the lipidic and carbohydrate profiles, such as insulin resistance and hyperglycemia, in addition to the central-type obesity constitute risk factors for the development of cardiovascular atherosclerotic diseases that modifY the life expectancy of these patients. In this work we aimed to study the serum lipid, apoprotein and lipoprotein profiles of 257 mv -positive patients (HIV +) and compare them to 56 healthy individuaIs, normolipidemic, which constituted the control group, and to classify the dyslipoproteinemias according to phenotypes in the mv + individuaIs. The mv -positive patients and the control individuaIs were previously submitted to a general clínical exam and the following serum biochemical ana1yses were done, after a 12-hour fast: total cholesterol (Tchol), HDL-cholesterol (HDL-chol), triglycerides (TG); LDL-chole~terol (LDL-chol), phospholipids (PL), free fatty acids (FFA), apolipoproteins AI (Apo AI) and B (Apo B) and lipoprotein "a" (Lp a). In the mv positive group the eletrophoretic separation of lipoproteins, followed by densitometric scanning of the LP bands, were carried out. The mv+ patient s innnunological evalyation was made through the counting of the lymphocytes CD4 and CD8 and quantification ofthe vkalload. Significant negative correlations were observed between the time of use of protease inhibitors and the concentrations of HDL-chol and Apo AI. The cholesterolemia was correlated in an inverse way with the viral load. Lipid and apoprotein modifications were observed in HIV+ patients regarding the controls: decrease of HDL-chol and Apo AI leveIs with increase of Tcho1/HDL-chol ratio; increase of VLDL-chol, TG and FFA concentrations. These results demonstra te that a greatpart of the HIV+ patients present lipidic alterarions characteristic of dyslipidemia, with a pro-atherogenic profile

ASSUNTO(S)

lipidios aids (doença) - brasil aterosclerose sindromes de deficiencia imunologica

ACESSO AO ARTIGO

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