Pharmacological evaluation of bee venom and melittin
AUTOR(ES)
Dantas, Camila G., Nunes, Tássia L.G.M., Nunes, Tâmara L.G.M., Paixão, Ailma O. da, Reis, Francisco P., L. Júnior, Waldecy de, Cardoso, Juliana C., Gramacho, Kátia P., Gomes, Margarete Z.
FONTE
Rev. bras. farmacogn.
DATA DE PUBLICAÇÃO
2014-01
RESUMO
The objective of this study was to identify the pharmacological effects of bee venom and its major component, melittin, on the nervous system of mice. For the pharmacological analysis, mice were treated once with saline, 0.1 or 1.2 mg/kg of bee venom and 0.1 mg/kg of melittin, subcutaneously, 30 min before being submitted to behavioral tests: locomotor activity and grooming (open-field), catalepsy, anxiety (elevated plus-maze), depression (forced swimming test) and apomorphine-induced stereotypy. Haloperidol, imipramine and diazepam were administered alone (positive control) or as a pre-treatment (haloperidol).The bee venom reduced motor activity and promoted cataleptic effect, in a similar manner to haloperidol.These effects were decreased by the pretreatment with haloperidol. Both melittin and bee venom decreased the apomorphine-induced stereotypies. The data indicated the antipsychotic activity of bee venom and melittin in a murine model.
Documentos Relacionados
- Antimicrobial activity of apitoxin, melittin and phospholipase A2 of honey bee (Apis mellifera) venom against oral pathogens
- Effect of staphylococcal delta-toxin and bee venom peptide melittin on leukotriene induction and metabolism of human polymorphonuclear granulocytes.
- Interaction of Bee Venom Melittin with Zwitterionic and Negatively Charged Phospholipid Bilayers: A Spin-Label Electron Spin Resonance Study
- Effect of bee venom on experimental arthritis.
- Pharmacological characterization of cnidarian extracts from the Caribbean Sea: evaluation of anti-snake venom and antitumor properties