Photoelectroanalytical Detection of Adrenaline Based on DNA and TiO 2 Nanoparticles Sensitized with Bis(ethylenedithio)tetrathiafulvalene Exploiting LED Light
AUTOR(ES)
Santos, Thiago Augusto D., Yotsumoto Neto, Sakae, Macena, Cleidivan S., Luz, Rita de Cássia S., Damos, Flávio S.
FONTE
J. Braz. Chem. Soc.
DATA DE PUBLICAÇÃO
2017-09
RESUMO
In this study, a photoelectroanalytical sensor for determination of adrenaline based on deoxyribonucleic acid (DNA) and anatase titanium dioxide (TiO2) nanoparticles sensitized with bis(ethylenedithio)tetrathiafulvalene (BEDT-TTF) was developed, which we henceforward call BEDT-TTF/DNA/TiO2/ITO. The photoelectroanalytical sensor showed high photocurrent to adrenaline under visible light emitting diode (LED) light irradiation in comparison to each component of the composite material. Under optimized conditions, the BEDT-TTF/DNA/TiO2/ITO sensor shows a linear response range from 10 nmol L-1 up to 100 µmol L-1 with a sensitivity of 8.1 nA L µmol-1 and limit of detection of 1 nmol L-1 for the detection of adrenaline. The photoelectrochemical sensor showed high photocurrent to adrenaline in comparison to photocurrent response to ascorbic acid and uric acid. The BEDT-TTF/DNA/TiO2/ITO photoelectrochemical sensor was successfully applied to urine samples, with recovery values between 96 and 106%.
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