Pleiotypic Control by Cyclic AMP: Interaction with Cyclic GMP and Possible Role of Microtubules
AUTOR(ES)
Kram, Raphael
RESUMO
Previous studies have shown that exogenous dibutyryl cyclic AMP inhibits the uptake of uridine, leucine, and 2-deoxyglucose by cultured mouse fibroblasts. 3′:5′-cyclic GMP is shown here to counteract these inhibitory effects as well as the inhibition of precursor transport and leucine incorporation into proteins produced by prostaglandin E1. We conclude, therefore, that cyclic GMP antagonizes the “pleiotypic” effects of cyclic AMP in these cells.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=433567Documentos Relacionados
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