pncA Mutations in Pyrazinamide-Resistant Mycobacterium tuberculosis Isolates in Portugal
AUTOR(ES)
Portugal, Isabel
FONTE
American Society for Microbiology
RESUMO
The nucleotide sequences of the pncA genes within 55 multidrug-resistant pyrazinamide-resistant Mycobacterium tuberculosis clinical isolates were determined. Fifty-three out of the 55 isolates were pyrazinamidase (PZase) negative. Four strains contained a wild-type pncA gene, and PZase activity was undetectable in two of these strains. Seven of the 18 identified pncA mutations found have not been described in previous studies.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=434191Documentos Relacionados
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