Polyomavirus middle tumor antigen increases responsiveness to growth factors.
AUTOR(ES)
Raptis, L
RESUMO
The middle tumor antigen (mT) of polyomavirus is unable to transform a clone of NIH 3T3 cells to anchorage independence (L. Raptis and J.B. Bolen, J. Virol. 63:753-758, 1989). However, this oncogene increased the responsiveness of these cells to the growth factors (alpha-like and beta-type transforming growth factors) produced by cells possessing the whole transforming region of polyomavirus. This resulted in the growth of NIH 3T3 cells, expressing mT under control of the dexamethasone-regulatable mouse mammary tumor virus promoter, in agar medium supplemented with these growth factors upon addition of the inducer. Therefore, mT, a transforming oncogene, is able to enhance the responsiveness of established cells to growth factors, a property previously attributed primarily to myc and other establishment type oncogenes.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=240629Documentos Relacionados
- A subclass of polyomavirus middle tumor antigen binds to DNA cellulose.
- Polyomavirus middle-sized tumor antigen modulates c-Jun phosphorylation and transcriptional activity.
- Responsiveness of articular cartilage from normal and inflamed mouse knee joints to various growth factors.
- Multimerization of polyomavirus middle-T antigen.
- Polyomavirus middle T-antigen NPTY mutants.
