Polyomavirus small T antigen enhances replication of viral genomes in 3T6 mouse fibroblasts.
AUTOR(ES)
Berger, H
RESUMO
Transfection of 3T6 cells with a cloned polyomavirus genome encoding only large T antigen resulted in DNA replication with only about 1/10 the efficiency of wild-type viral DNA coding for all three T antigens. This replication defect was at least in part overcome by the simultaneous transfections of polyomavirus genomes which allowed the expression of small T antigen. We conclude that polyomavirus small T antigen has a (probably indirect) role in replication.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=288954Documentos Relacionados
- Regulation of histone mRNA production and stability in serum-stimulated mouse 3T6 fibroblasts.
- Dynamics of pyrimidine deoxynucleoside triphosphate pools in relationship to DNA synthesis in 3T6 mouse fibroblasts.
- Polyomavirus large and small T antigens cooperate in induction of the S phase in serum-starved 3T3 mouse fibroblasts.
- Extracellular ATP induces the release of calcium from intracellular stores without the activation of protein kinase C in Swiss 3T6 mouse fibroblasts.
- Molecular cloning and characterization of small polydisperse circular DNA from mouse 3T6 cells.