Polypeptide specificity of antiviral serum antibodies in children naturally infected with human rotavirus.
AUTOR(ES)
Brüssow, H
RESUMO
Reassortants between serotype 3 SA11 and serotype 6 NCDV rotaviruses were used to determine the relative amounts of serum-neutralizing antibody to VP4 and VP7 of serotype 3 SA11 rotavirus in children after natural rotavirus exposure. Sera from Ecuadorian children of a population-based study and sera from children of a hospital-based study in Germany (excluding diarrhea patients) demonstrated high titers of VP7-specific but only low titers of VP4-specific antibodies. In contrast, paired sera from German children hospitalized with a symptomatic primary rotavirus gastroenteritis demonstrated a titer increase to VP4 more frequently than to VP7 protein by neutralization test and immunoblotting. For these rotavirus patients, we provided, previously, direct evidence for the development of cross-neutralizing antibodies.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=247876Documentos Relacionados
- Prevalent patterns of serotype-specific seroconversion in Mexican children infected with rotavirus.
- Homotypic serum antibody responses to rotavirus proteins following primary infection of young children with serotype 1 rotavirus.
- Relative concentrations of serum neutralizing antibody to VP3 and VP7 proteins in adults infected with a human rotavirus.
- Development of neutralizing antibodies and group A common antibodies against natural infections with human rotavirus.
- Role of coproantibody in clinical protection of children during reinfection with rotavirus.