Positioning of two alpha subunit carboxy-terminal domains of RNA polymerase at promoters by two transcription factors
AUTOR(ES)
Murakami, Katsuhiko
FONTE
The National Academy of Sciences of the USA
RESUMO
Interactions between the cAMP receptor protein (CRP) and the carboxy-terminal regulatory domain (CTD) of Escherichia coli RNA polymerase α subunit were analyzed at promoters carrying tandem DNA sites for CRP binding using a chemical nuclease covalently attached to α. Each CRP dimer was found to direct the positioning of one of the two α subunit CTDs. Thus, the function of RNA polymerase may be subject to regulation through protein–protein interactions between the two α subunits and two different species of transcription factors.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=23438Documentos Relacionados
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