Positively Charged Termini of the L2 Minor Capsid Protein Are Necessary for Papillomavirus Infection

AUTOR(ES)

Roden, Richard B. S.

FONTE

American Society for Microbiology

RESUMO

Coexpression of bovine papillomavirus L1 with L2 mutants lacking either eight N-terminal or nine C-terminal amino acids that encode positively charged domains resulted in wild-type levels of viral genome encapsidation. Despite wild-type binding to the cell surface, the resulting virions were noninfectious. An L2 mutant encoding a scrambled version of the nine C-terminal residues restored infectivity, in contrast to an L2 mutant encoding a scrambled version of the N-terminal residues.

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