Posttranscriptional Selection of Simian Virus 40-Specific RNA
AUTOR(ES)
Khoury, George
RESUMO
Analysis of the viral-specific RNA in simian virus 40(SV40)-infected monkey kidney cells indicated the extensive transcription of both DNA strands. These symmetrically transcribed sequences were localized in the nucleus of infected cells, whereas only the “true” early and late SV40 transcripts were found in the cytoplasm. These results suggest that selective posttranscriptional degradation and/or transport occurs after transcription of the viral DNA. On the basis of hybridization experiments with cytoplasmic RNA and the separated strands of the SV40 Hin fragments, the early SV40 region appears to include all of Hin fragments A, H, I, and B (48% of the genome), whereas the late region is represented in Hin fragments C, D, E, K, F, J, and G (52% of the genome).
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=354473Documentos Relacionados
- Characterization of the 5'-terminal capped structures of late simian virus 40-specific mRNA.
- Characterization of Two Simian Virus 40-Specific RNA Molecules from Infected BS-C-1 Cells
- Methylated simian virus 40-specific RNA from nuclei and cytoplasm of infected BSC-1 cells.
- Simian virus 40-specific proteins in the membranes of simian virus 40-transformed hamster and mouse cells.
- Simian virus 40-specific ribosome-binding proteins induced by a nondefective adenovirus 2-simian virus 40 hybrid.