Premalignant melanosis of the conjunctiva and the cornea in xeroderma pigmentosum.

AUTOR(ES)

Paridaens, A D

RESUMO

Xeroderma pigmentosum is a rare autosomal recessive dermatosis. The neoplastic changes in sunlight-exposed areas of the skin and eyes may be related to the impaired replication of ultraviolet radiation-damaged DNA. A 38-year-old Greek woman is reported with a mild form of xeroderma pigmentosum and primary acquired melanosis with atypia of her right limbal conjunctiva and cornea. The development of this precursor of conjunctival malignant melanoma in a xeroderma pigmentosum patient may support the putative role of sunlight exposure in malignant transformation of conjunctival melanocytes.

Documentos Relacionados

• Carrier detection in xeroderma pigmentosum.
• Ocular melanomas in xeroderma pigmentosum.
• Characterization of a splicing mutation in group A xeroderma pigmentosum.
• Sensitivity to ultraviolet radiation in a dominantly inherited form of xeroderma pigmentosum.
• Spontaneous regression of metastatic malignant melanoma in 2 sibs with xeroderma pigmentosum.