Proline and glucose transport by renal membranes from dogs with spontaneous idiopathic Fanconi syndrome.

AUTOR(ES)

Medow, M S

RESUMO

The uptake of proline and glucose by renal brush border membrane vesicles isolated from Basenji dogs exhibiting a spontaneous Fanconi syndrome was examined. The magnitude of the 1-min, Na+-gradient uptake of proline (0.02 mM) and glucose (1.0 mM) by vesicles from affected dog kidney was lower than normal. Concentration-dependent 15-sec uptake in vesicles from normal and affected dogs reveals a two-component transport system for proline and glucose. Kinetic analysis shows altered Km and Vmax values for both proline and glucose transport in the affected dogs. The data suggest that, in this model of Fanconi syndrome, the defective renal reabsorption of proline and glucose is associated with an alteration of luminal transport system.

Documentos Relacionados

• Oral carnitine therapy in children with cystinosis and renal Fanconi syndrome.
• Plasma and muscle free carnitine deficiency due to renal Fanconi syndrome.
• Developmental aspects of proline transport in rat renal brush border membranes.
• Membrane permeability as a cause of transport defects in experimental Fanconi syndrome. A new hypothesis.
• Recurrent lobar pneumonia associated with idiopathic Eaton-Lambert syndrome.