Prolonged reduction in polymorphonuclear adhesion following oral colchicine.

AUTOR(ES)

Fordham, J N

RESUMO

Polymorphonuclear leucocyte (PMN) function was studied in 7 healthy subjects before and after 5 mg of colchicine taken in divided doses over 24 hours. Mean adherence to nylon fibre colums fell from a pretreatment level of 51% to 33.6% by day 1, remained low (31.8%) at day 5, and returned to pretreatment levels only by about day 9. Random motility (agarose plate method) fell from 932 micrometers to 688 micrometers by day 1, but had returned to normal by day 5. Directed migration and the phagocytic index (opsonised Candida albicans method) were not affected by colchicine treatment. In this marked and prolonged reduction in PMN adhesion implies an influence on maturing PMN precursors in bone marrow. Adherence to nylon fibres may reflect in-vivo properties of PMN which are important in the pathogenesis of acute gouty arthritis.

Documentos Relacionados

• Abnormal mobility of neonatal polymorphonuclear leukocytes. Relationship to impaired redistribution of surface adhesion sites by chemotactic factor or colchicine.
• Direct photoaffinity labeling of tubulin with colchicine.
• Acute gout during hypouricaemic therapy: prophylaxis with colchicine.
• Changes in membrane microviscosity associated with phagocytosis: effects of colchicine.
• Secretion of macrophage neutral proteinase is enhanced by colchicine.