Prolonging morbidity in rabid dogs by intrathecal injection of attenuated rabies vaccine.

AUTOR(ES)

Baer, G M

RESUMO

Dogs vaccinated intrathecally with attenuated rabies vaccine developed antibodies that were detected in the cerebrospinal fluid, blood, and brain; dogs similarly vaccinated but with an inactivated vaccine developed no antibodies in the brain. When the attenuated vaccine was administered to rabid dogs, a prolongation of the morbidity period was noted and, in some dogs, recovery from the disease. Rhesus monkeys died when administered any of the available attenuated vaccines intrathecally, and further studies with that species could not be undertaken.

Documentos Relacionados

• Prophylactic immunization of humans against rabies by intradermal inoculation of human diploid cell culture vaccine.
• Evaluation in volunteers of a candidate live oral attenuated Salmonella typhi vector vaccine.
• Modification of antibody response to type III pneumopolysaccharide by route of injection of pertussis vaccine.
• Progress toward the development of a genetically engineered attenuated hepatitis A virus vaccine.
• Improved method for production of attenuated Venezuelan equine encephalomyelitis (TC-83 strain) vaccine.