Prospero is a panneural transcription factor that modulates homeodomain protein activity
AUTOR(ES)
Hassan, Bassem
FONTE
The National Academy of Sciences of the USA
RESUMO
The panneural protein Prospero is required for proper differentiation of neuronal lineages and proper expression of several genes in the nervous system of Drosophila. Prospero is an evolutionarily conserved, homeodomain-related protein with dual subcellular localization. Here we show that Prospero is a sequence-specific DNA-binding protein with novel sequence preferences that can act as a transcription factor. In this role, Prospero can interact with homeodomain proteins to differentially modulate their DNA-binding properties. The relevance of functional interactions between Prospero and homeodomain proteins is supported by the observation that Prospero, together with the homeodomain protein Deformed, is required for proper regulation of a Deformed-dependent neural-specific transcriptional enhancer. We have localized the DNA-binding and homeodomain protein-interacting activities of Prospero to its highly conserved C-terminal region, and we have shown that the two regulatory capacities are independent.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=23559Documentos Relacionados
- Identification of MoKA, a Novel F-Box Protein That Modulates Krüppel-Like Transcription Factor 7 Activity
- Pan-neural Prospero terminates cell proliferation during Drosophila neurogenesis
- Homeodomain-Interacting Protein Kinase 1 Modulates Daxx Localization, Phosphorylation, and Transcriptional Activity
- Hepatocyte nuclear factor 6, a transcription factor that contains a novel type of homeodomain and a single cut domain.
- Yeast GAL11 protein is a distinctive type transcription factor that enhances basal transcription in vitro.