Protection of mice from infection with Streptococcus pneumoniae by anti-phosphocholine antibody.
AUTOR(ES)
Yother, J
RESUMO
Anti-phosphocholine (PC) antibody mediated protection against many strains of Streptococcus pneumoniae, and hybridoma anti-PC antibodies protected mice from fatal infections with types 1 and 3 S. pneumoniae. Live types 1, 3, 5, 6A, and 19F S. pneumoniae had similar amounts of surface PC accessible to antibody. Furthermore, mice expressing the X-linked immunodeficiency (xid) of the CBA/N strain were found to be more susceptible to infection with S. pneumoniae of types 3, 6A, and 19F than were immunologically normal mice. The only exception to these results was with the type 5 strain, which was highly virulent for both xid and normal mice. In addition, we were unable to protect mice against infection with the type 5 strain by using anti-PC antibody.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=351201Documentos Relacionados
- Mouse antibody to phosphocholine can protect mice from infection with mouse-virulent human isolates of Streptococcus pneumoniae.
- Protection of mice against experimental cryptococcosis by anti-Cryptococcus neoformans monoclonal antibody.
- Epidemiological studies of Streptococcus pneumoniae in infants: development of antibody to phosphocholine.
- Passive protection of chickens against Eimeria tenella infection by monoclonal antibody.
- Blocking of pregnancy in mice by immunization with anti-idiotype directed against monoclonal anti-progesterone antibody.
