Proteolytic action of Legionella pneumophila on human serum proteins.
AUTOR(ES)
Müller, H E
RESUMO
Proteolysis by four strains of Legionella pneumophila, the etiological agent of Legionnaires disease, was studied by the method of immunoelectrophoresis. Twenty-three human serum proteins were tested as substrates. Five proteins were degraded: alpha 1-acid glycoprotein, alpha 1-antichymotrypsin, beta-lipoprotein, beta 1E-globulin, and beta 2-glycoprotein-I. Moreover, the degradation of alpha 1-antichymotrypsin was demonstrated by investigation of an enzyme-blocking test. It is suggested that the proteolytic activity of L. pneumophila may bear some relationship to its pathogenic activity.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=550720Documentos Relacionados
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