QacA Multidrug Efflux Pump from Staphylococcus aureus: Comparative Analysis of Resistance to Diamidines, Biguanidines, and Guanylhydrazones
AUTOR(ES)
Mitchell, Bernadette A.
FONTE
American Society for Microbiology
RESUMO
The staphylococcal multidrug efflux pump QacA mediates resistance to a broad spectrum of monovalent and divalent antimicrobial cations. Resistance toward various classes of these compounds identified features of the substrate that may be important for interaction with QacA. Analysis of combinations of two substrates suggested that the same mechanism is used for the extrusion of different classes of compounds.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=105442Documentos Relacionados
- Multidrug resistance proteins QacA and QacB from Staphylococcus aureus: membrane topology and identification of residues involved in substrate specificity.
- Organization of the Antiseptic Resistance Gene qacA and Tn552-Related β-Lactamase Genes in Multidrug- Resistant Staphylococcus haemolyticus Strains of Animal and Human Origins
- Phenothiazines and Thioxanthenes Inhibit Multidrug Efflux Pump Activity in Staphylococcus aureus
- Mycobacterium tuberculosis efpA encodes an efflux protein of the QacA transporter family.
- Fluoroquinolone resistance protein NorA of Staphylococcus aureus is a multidrug efflux transporter.
