QSAR: a abordagem de Hansch

AUTOR(ES)

Tavares, Leoberto Costa

FONTE

Química Nova

DATA DE PUBLICAÇÃO

2004-08

RESUMO

The Hansch Analysis, also known by QSAR-2D, is an extremely effective tool in the identification and/or improvement of the pharmacological or toxicological profile of xenobiotics. This article presents the theme didactically and with enough detail to clarify the conceptual basis of Hansch Analysis. Besides, it shows the application of the technique in measuring the influence of physicochemical properties on the biological activity of compounds with pharmacological interest.

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